Synthesis of 10-hydroxy-cis-8-decene-4,6-diynoic and 9-hydroxy-cis-7-nonene-3,5-diynoic acids.
نویسندگان
چکیده
منابع مشابه
Synthesis of 1,2,3,4,5,6,7,8-Octahydro-9-Ethoxy-10-Hydroxy-1-Anthracenone[OEHA]
Anthralin and some of its derivatives have implied antipsoriatic effect in clinical and pharmaceutical studies. Anthralin is synthesized by different strategies. In this work we report the synthesis of "OEHA" as a precursor of another biological active compound.
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An efficient synthesis of the 1-hydroxy-2-(prop-2'-enyl)9-anthrone is described. Selective nitration of anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-9,10-anthraquinone in good yield as the key intermediate. Reaction with allyl bromide/K2CO3 and subsequent selective reduction accompanie...
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Coumarin derivatives are used as fluorescent dyes and medicines. They also have some notable physiological effects, including the acute hepatoxicity and carcinogenicity of certain aflatoxins, the anticoagulant action of dicoumarol, and the antibiotic activity of novobicin and coumerymycin A1. Because the number of drug resistant strains is increasing at present, the synthesis of new antibacteri...
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Enantiopure α-hydroxy acids (AHAs) are versatile building blocks in organic synthesis. They are used for obtaining pharmaceutically and biologically active substances, such as vitamins. α-Hydroxy acids are easily synthesized from cyanohydrins. Thus, molecules with cyanohydrin substructures are interesting intermediates for the synthesis of AHAs. Usually, cyanohydrins are prepared by the additio...
متن کاملEpimerization of trans-4-hydroxy-L-proline to cis-4-hydroxy-D-proline during acid hydrolysis of collagen.
1. trans-4-Hydroxy-r,-proline is epimerized to &+hydroxy-n-proline under the conditions generally used for the hydrolysis of proteins for analyses of amino acids. 2. The cis epimer elutes from a column of UR-30 resin on a Beckman amino acid analyzer at the same time as threonine and hence would be undetected. 3. About 8% of the trans-4-hydroxy-L-proline in collagen can be epimerized to c&4-hydr...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1975
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.39.2247